Model-based clustering of array CGH data
نویسندگان
چکیده
منابع مشابه
Model-based clustering of array CGH data
MOTIVATION Analysis of array comparative genomic hybridization (aCGH) data for recurrent DNA copy number alterations from a cohort of patients can yield distinct sets of molecular signatures or profiles. This can be due to the presence of heterogeneous cancer subtypes within a supposedly homogeneous population. RESULTS We propose a novel statistical method for automatically detecting such sub...
متن کاملWeighted clustering of called array CGH data
Array comparative genomic hybridization (aCGH) is a laboratory technique to measure chromosomal copy number changes. A clear biological interpretation of the measurements is obtained by mapping these onto an ordinal scale with categories loss/normal/gain of a copy. The pattern of gains and losses harbors a level of tumor specificity. Here, we present WECCA (weighted clustering of called aCGH da...
متن کاملWeighted clustering of called array CGH data.
Array comparative genomic hybridization (aCGH) is a laboratory technique to measure chromosomal copy number changes. A clear biological interpretation of the measurements is obtained by mapping these onto an ordinal scale with categories loss/normal/gain of a copy. The pattern of gains and losses harbors a level of tumor specificity. Here, we present WECCA (weighted clustering of called aCGH da...
متن کاملEvaluating array-CGH based clustering of tumors
DNA preparation to cancer profiles •Many of the changes in the genome associated to cancer can be seen by making gene copy number measurements. Increased copy numbers of genes are associated with oncogenes and decreased copy numbers are associated with tumor suppressor genes. •Array-based Comparative Genomic Hybridization (arrayCGH), introduced in the late nineties, allows efficient characteriz...
متن کاملModel based approaches to array CGH data analysis
DNA copy number alterations (CNAs) are genetic changes that can produce adverse effects in numerous human diseases, including cancer. CNAs are segments of DNA that have been deleted or amplified and can range in size from one kilobases to whole chromosome arms. Development of array comparative genomic hybridization (aCGH) technology enables CNAs to be measured at sub-megabase resolution using t...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2009
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btp205